Research

Slideflow is built on peer-reviewed science from the team behind the open-source framework, and on a growing body of independent research from labs worldwide.

Our publications

Peer-reviewed from the start.

  1. 01
    Dolezal JM, Kochanny S, Dyer E, Ramesh S, Srisuwananukorn A, et al.BMC Bioinformatics2024
  2. 02
    Dolezal JM, Srisuwananukorn A, Karpeyev D, et al.Nature Communications2022Cited by 179
  3. 03
    Dolezal JM, Wolk R, Hieromnimon HM, et al.npj Precision Oncology2023Cited by 83
  4. 04
    Howard FM, Dolezal JM, Kochanny S, Khramtsova G, et al.npj Breast Cancer2023Cited by 69
  5. 05
  6. 06
    Deep learning applications in visual data for benign and malignant hematologic conditions: a systematic review and visual glossary.
    Srisuwananukorn A, Salama ME, et al.Haematologica2023Cited by 27
  7. 07
    Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology.
    Ramesh S, Dyer E, Pomaville M, Doytcheva K, et al.npj Precision Oncology2024Cited by 18
  8. 08
  9. 09
    Developing a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning.
    Choudhury A, Dolezal JM, Dyer E, Kochanny S, et al.eClinicalMedicine2024Cited by 12
  10. 10
    Virtual multiplex immunofluorescence identifies lymphocyte subsets predictive of response to neoadjuvant therapy.
    Li A, Torcasso A, Woodard L, et al.Therapeutic Advances in Medical Oncology2025Cited by 3
  11. 11
    Integration of gene expression and digital histology to predict treatment-specific responses in breast cancer.
    Howard FM, Dolezal JM, Hieromnimon HM, Venters S, et al.medRxiv2025
  12. 12
    Artificial intelligence differentiates prefibrotic primary myelofibrosis with thrombocytosis from essential thrombocythemia using digitized bone marrow biopsy images.
    Srisuwananukorn A, Loscocco GG, Dolezal JM, et al.Leukemia2026
  13. 13
    Development and validation of a multimodal clinical, pathologic, and genomic model for breast cancer recurrence (AI-Path).
    Nguyen NK, Li A, Kochanny S, Dolezal JM, Ramesh S, et al.medRxiv2026
Built on Slideflow

Used in research worldwide.

Slideflow is cited or extended by more than 100 studies. A selection of independent work is listed below, grouped by focus. The complete, always-current list lives on Google Scholar.

Methods & tools 28

  • LazySlide: accessible and interoperable whole-slide image analysis.Zheng, Abila, Chrenková, Buljan, Winkler, et al. · Nature · 2026
  • The impact of tissue detection on diagnostic AI algorithms in (prostate) digital pathology.Boman, Mulliqi, Blilie, Ji, Szolnoky, et al. · Scientific Reports · 2026
  • Comparative analysis of pathology foundation models for automated detection of tertiary lymphoid structures in H&E digital pathology.Guan, Sun, Belete, Muthuswamy, et al. · Comput. & Structural Biotech. J. · 2026
  • DIANNE: segmentation-free localization of histology differential attributes.Domanskyi, Rubinstein, Sheridan, Thiesen, et al. · bioRxiv · 2026
  • CellDX AI Autopilot: agent-guided training and deployment of pathology classifiers.Pchelnikov, Pchelnikov · arXiv · 2026
  • From binary to continuous: learning to continuously quantify histopathological patterns from binary labeled images.Acosta-Velasquez, Cano, Romero, et al. · IEEE 23rd ISBI · 2026
  • Deep learning-integrated digital pathology system for early-stage cancer screening using high-resolution tissue images.Rosaline, Hazaimeh, Sobti, et al. · IEEE (Conf. on AI) · 2026
  • Decoding cancer tissues: a comparative deep learning view of breast histopathology.Malik, Khetan, Oberoi, et al. · IEEE (Conf. on AI) · 2026
  • Preprocessing in colorectal cancer histopathology: a prerequisite for effective computational analysis.Kumar S, Mishra PK · Taylor & Francis (book) · 2026
  • Interpretable AI driven histopathological image analysis.Lehtonen O · Univ. of Helsinki · 2026
  • Integrative whole slide image and spatial transcriptomics analysis with QuST and QuPath.Huang CH, Lichtarge, Fernandez · npj Precision Oncology · 2025
  • Self-supervised learning for data augmentation in histopathology image segmentation.Almubarak HA · Scientific Reports · 2025
  • PathBench-MIL: a comprehensive AutoML and benchmarking framework for multiple instance learning in histopathology.Brussee, Valkema, Weijer, et al. · arXiv · 2025
  • ORCA: a comprehensive AI-driven platform for digital pathology analysis and biomarker discovery.Shaker, AbouZleikha, Shaker · arXiv · 2025
  • Reusable specimen-level inference in computational pathology.Kaczmarzyk, Sharma, Koo, Saltz · arXiv · 2025
  • WSInsight as a cloud-native pipeline for single-cell pathology inference on whole-slide images.Huang CH, Awosika, Fernandez · bioRxiv · 2025
  • Toward quantum-enabled biomarker discovery: an outlook from q4bio.Shah, Teo, Robinett, Madejski, et al. · arXiv · 2025
  • Histolytics: a panoptic spatial analysis framework for interpretable histopathology.Lehtonen, Nordlund, Salloum, Kalliala, et al. · Comput. & Structural Biotech. J. · 2025
  • The 3D visualization of digitalized pathological serial sections on a native resolution.Vincze, Burian, et al. · IEEE (World Symp.) · 2025
  • Dynamic graph representation for WSI classification: a knowledge-aware attention mechanism.Kumar TR, Mahaveerakannan · IEEE (Intl. Conf.) · 2025
  • A dataset for artefact detection of whole slide images in digital pathology.Nguyen, Mahmoudpour, Courtoy, et al. · IEEE QoMEX · 2025
  • Parallel computing for efficient histopathological image classification: GPU-accelerated deep learning for breast cancer detection.Dupljak, Domazet · Springer (IbPRIA-type conf.) · 2025
  • Converting whole slide images from DICOM to ScanScope Virtual Slide-like TIFF: a practical workaround.Chauveau B · Virchows Archiv · 2025
  • Advances in risk prediction, explainability, and accessible AI in computational pathology.Kaczmarzyk JR · Stony Brook (ProQuest) · 2025
  • Multimodal co-attention fusion network with online data augmentation for cancer subtype classification.Ding, Li, Wang, Ying, et al. · IEEE Trans. Medical Imaging · 2024
  • Open and reusable deep learning for pathology with WSInfer and QuPath.Kaczmarzyk, O'Callaghan, Inglis, Gat, et al. · npj Precision Oncology · 2024
  • Generalizing AI-driven assessment of immunohistochemistry across immunostains and cancer types: a universal IHC analyzer.Brattoli, Mostafavi, Lee, Jung, Ryu, et al. · arXiv · 2024
  • Développement d'un plugin pour le visualisateur d'images histopathologiques Sectra (decision support based on DL).Borrajo E · HES-SO Valais-Wallis · 2024

Clinical applications 25

  • Weakly supervised deep learning for cutaneous squamous and basal cell carcinoma in whole-slide histopathology.Petzold, Wessely, Schliep, Jiang, et al. · Journal of Pathology · 2026
  • AI-based histopathology analysis predicts checkpoint inhibitor response in advanced melanoma and identifies patterns associated with response.Schuiveling, Van Duin, Ter Maat, et al. · European Journal of Cancer · 2026
  • Domain generalisation challenges in breast cancer molecular classification using foundation models.Fernandez-Romero, Ramos-Berciano, et al. · Medical & Biological Eng. & Computing · 2026
  • Leveraging interpretable AI for deciphering signature histopathologic patterns (LCV vs MVO).Gehlhausen, Luyten, Deng, et al. · Journal (Dermatology, Wiley) · 2026
  • Pathogenomic analysis reveals clinically relevant epithelial-mesenchymal plasticity in esophageal squamous cell carcinoma.Chen R, Xie, Ning, Yang, Su, Chen, et al. · (journal via PMC) · 2026
  • Integrating quantitative histology with clinical data improves prediction of cervical intraepithelial neoplasia regression.Lehtonen, Nordlund, Kahelin, Bergqvist, Aro, et al. · medRxiv · 2026
  • Explainable histomorphology-based survival prediction of glioblastoma, IDH-wildtype.Redlich, Feuerhake, Nikolin, Schaadt, et al. · arXiv · 2026
  • Learning the forest before the trees: artificial intelligence and thymic tumour pathology.Schulz, Foersch · Annals of Oncology · 2026
  • Multiple instance learning using pathology foundation models effectively predicts kidney disease diagnosis and clinical classification.Kurata, Mimura, Kodera, Abe, Yamada, et al. · Scientific Reports · 2025
  • An artificial intelligence model of whole-slide pathology specimens differentiating cutaneous high-grade squamous proliferations.Petzold, Wessely, Erdmann, Schliep, et al. · Virchows Archiv · 2025
  • Deep learning-based classification of early-stage mycosis fungoides and benign inflammatory dermatoses on H&E WSIs.Doeleman, Brussee, Hondelink, et al. · J. Investigative Dermatology · 2025
  • Translating features to findings: deep learning for melanoma subtype prediction.Guermazi, Khemchandani, Wahood, Nguyen, et al. · Dermatopathology (MDPI) · 2025
  • Deep learning discriminates thymic epithelial tumors histological subtypes using digital pathology.Sacco, Pietroluongo, Di Lello, Marino, et al. · Annals of Oncology · 2025
  • Deep learning-based classification of colorectal cancer in histopathology images.Truong Le, Nguyen-Truong, Le Phan, et al. · Biology Methods and Protocols · 2025
  • Weakly supervised deep learning-based detection of serous tubal intraepithelial carcinoma in fallopian tubes.Valesano, Skala, Yousif · J. Pathology Informatics · 2025
  • Cross-domain approach for automated thyroid classification using Diff-Quick images.Do TH, Le, Dang, Nguyen, Do · Mathematics (MDPI) · 2025
  • Multiple-instance learning for thyroid gland disease classification: a hands-on experience.Lysukhin, Varlamov, Yakimov, et al. · Computers in Biology and Medicine · 2025
  • Implementing trust in NSCLC diagnosis with a conformalized uncertainty-aware AI framework in whole-slide images.Zhang, Wang, Yan, Najdawi, Zhou, et al. · Research Square · 2025
  • Predictive modelling of colorectal cancer using tumor infiltrating lymphocytes: a deep learning approach.Jayasri VS, Ria, et al. · IEEE (Intl. Conf.) · 2025
  • Automated identification of histological lesions in nonmodel organisms: reinvigorating environmental science.Liboureau, Tanabe, Riccardi, et al. · Environ. Science & Tech. Letters · 2025
  • Demographic bias in misdiagnosis by computational pathology models.Vaidya, Chen, Williamson, Song, et al. · Nature Medicine · 2024
  • Deep learning histology for prediction of lymph node metastases and tumor regression after neoadjuvant FLOT therapy.Jung, Pisula, Beyerlein, Lukomski, Knipper, et al. · Cancers · 2024
  • AI-powered classification of ovarian cancers based on histopathological images.Kussaibi, Alibrahim, Alamer, Alhaji, et al. · medRxiv · 2024
  • Predicting the HER2 status in oesophageal cancer from tissue microarrays using convolutional neural networks.Pisula, Datta, Valdez, et al. · British Journal of Cancer · 2023
  • Performance comparison between multi-center histopathology datasets of a weakly-supervised DL model for pancreatic ductal adenocarcinoma detection.Carrillo-Perez, Ortuno, Börjesson, Rojas, et al. · Cancer Imaging · 2023

Reviews & surveys 19

  • Artificial intelligence in medical diagnostics: foundations, clinical applications, and future directions.Dorota, Roshan, Aebisher · Applied Sciences (MDPI) · 2026
  • The role of whole slide imaging in AI-based digital pathology: current challenges and future directions.Omoush, Alzyoud, El-Omari, et al. · J. Molecular Pathology · 2026
  • A comprehensive review of multimodal large language models for medical imaging and omics data.Vavekanand R · Arch. Computational Methods in Eng. · 2026
  • Exploring transparency in pathological image analysis: a comprehensive review of explainable AI (XAI) techniques.Yuan, Gu, Han, Du, Grzegorzek, et al. · Computer Science Review · 2026
  • Smart lies and sharp eyes: pragmatic artificial intelligence for cancer pathology — promise, pitfalls, and access pathways.Bani MA · Cancers (MDPI) · 2026
  • Cracking the code: computational image analysis tools for histopathological and morphometric insights.de Almeida, Dos Santos, Barreto-Vieira · Journal of Imaging (MDPI) · 2026
  • Artificial intelligence and machine learning in diagnostic pathology: a systematic review.Mishra V, Jayant, Dash, Chaudhary, Babaria, et al. · Cureus · 2026
  • AI-driven discovery in protein science for immunology and infectious disease research.Helmy, Shafei, Pellegrina, Jin, et al. · Frontiers in Immunology · 2026
  • Current AI technologies in cancer diagnostics and treatment.Tiwari, Mishra, Kuo · Molecular Cancer · 2025
  • Artificial intelligence-based biomarkers for treatment decisions in oncology.Ligero, El Nahhas, Aldea, Kather · Trends in Cancer · 2025
  • Advancing open-source visual analytics in digital pathology: a systematic review of tools, trends, and clinical applications.Ahmad, Alzubaidi, Al-Thelaya, Calì, et al. · J. Pathology Informatics · 2025
  • The application of artificial intelligence in periprosthetic joint infection.Li P, Wang, Zhao, Hao, Chai, et al. · Journal of Advanced Research · 2025
  • Artificial intelligence in medicine: a specialty-level overview of emerging AI trends.Popover, Wallace, Feldman, et al. · JSLS · 2025
  • Harnessing artificial intelligence in head and neck oncology practice: data, diagnosis, and therapy.Rao KN, Kirsch, Mahmood, et al. · Otolaryngologic Clinics of N. America · 2025
  • Computer vision methods under rapid evolution for pathology image tasks.Maher, Scolyer, Liu · Histopathology · 2025
  • Survey on whole slide image in pathology: deep learning and machine learning approaches.Mosayyebpour, Nouri, Parham, et al. · ResearchGate (preprint) · 2025
  • Artificial intelligence applications in oral cancer and oral dysplasia.Viet, Zhang, Dharmaraj, Li, et al. · Tissue Engineering Part A · 2024
  • The quest for the application of artificial intelligence to whole slide imaging.Faa, Castagnola, Didaci, Coghe, Scartozzi, et al. · Algorithms (MDPI) · 2024
  • Perspective chapter: computer vision-based digital pathology for central nervous system tumors — state-of-the-art and current advances.Hieber, Holl, Nickl, et al. · IntechOpen · 2024